2025
Cantoni C, Smirnov RA, Firulyova M, Andhey PS, Bradstreet TR, Esaulova E, Terekhova M, Schwarzkopf EA, Abdalla NM, Kleverov M, Sabatino JJ Jr, Liu K, Schwab N, Meyer Zu Hörste G, Cross AH, Artyomov MN, Edelson BT, Wu GF. A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations. J Clin Invest. 2025 Jan 2;135(1):e177793. doi: 10.1172/JCI177793. PMID: 39744938.
2024
Ghezzi L, Tosti V, Shi L, Cantoni C, Mikesell R, Lancia S, Zhou Y, Obert K, Dula C, Sen MK, Ge A, Tolentino M, Bollman B, Don AS, Matarese G, Colamatteo A, La Rocca C, Lepore MT, Raji CA, Rahmani F, Wu GF, Naismith RT, Fontana L, Cross AH, Salter A, Piccio L. Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2025 Jan 16;96(2):158-169. doi: 10.1136/jnnp-2024-333465. PMID: 39137977.
Martin K, Cofield SS, Cross AH, Goss AM, Raji CA, Rinker JR, Wu GF, Blair J, Fuchs A, Ghezzi L, Green K, Pace F, Pastori G, Taylor MG, Piccio L, Wingo BC. Functional outcomes of diets in multiple sclerosis (FOOD for MS): Protocol for a parallel arm randomized feeding trial for low glycemic load and calorie restriction. Contemp Clin Trials. 2024 Aug;143:107584. doi: 10.1016/j.cct.2024.107584. Epub 2024 May 29. PMID: 38821260.
Trivedi RR, Archambault AS, Pavlak C, Gastaldi M, Cantoni C, Ghezzi L, Cross AH, Miller TM, Wu GF. Prevalence of anti-myelin oligodendrocyte glycoprotein antibodies across neuroinflammatory and neurodegenerative diseases. J Neurol Sci. 2024 Jun 15;461:123041. doi: 10.1016/j.jns.2024.123041. Epub 2024 May 9. PMID: 38744216.
Xue X, Demirci D, Lenze EJ, Reynolds Iii CF, Mulsant BH, Wetherell JL, Wu GF, Blumberger DM, Karp JF, Butters MA, Mendes-Silva AP, Vieira EL, Tseng G, Diniz BS. Sex differences in plasma proteomic markers in late-life depression. Psychiatry Res. 2024 Apr;334:115773. doi: 10.1016/j.psychres.2024.115773. Epub 2024 Feb 7. PMID: 38350292.
2023
Holloman JP, Dimas SH, Archambault AS, Filipello F, Du L, Feng J, Zhao Y, Bollman B, Piccio L, Steelman AJ, Hu H, Wu GF. Transient Receptor Potential Vanilloid 4-Dependent Microglial Function in Myelin Injury and Repair. Int J Mol Sci. 2023 Dec 4;24(23):17097. doi: 10.3390/ijms242317097. PMID: 38069420.
Jiang H, Zhou C, Qiu L, Gropler RJ, Brier MR, Wu GF, Cross AH, Perlmutter JS, Benzinger TLS, Tu Z. Quantitative Analysis of S1PR1 Expression in the Postmortem Multiple Sclerosis Central Nervous System. ACS Chem Neurosci. 2023 Nov 15;14(22):4039-4050. doi: 10.1021/acschemneuro.3c00581. Epub 2023 Oct 26. PMID: 37882753.
Lu P, Zhao Y, Xie Z, Zhou H, Dong X, Wu GF, Kim BS, Feng J, Hu H. MrgprA3-expressing pruriceptors drive pruritogen-induced alloknesis through mechanosensitive Piezo2 channel. Cell Rep. 2023 Apr 25;42(4):112283. doi: 10.1016/j.celrep.2023.112283. Epub 2023 Mar 22. PMID: 36961815.
Wu GF. The cerebrospinal fluid immune cell landscape in animal models of multiple sclerosis. Front Mol Neurosci. 2023 Apr 12;16:1143498. doi: 10.3389/fnmol.2023.1143498. PMID: 37122618.
Hu X, Du L, Liu S, Lan Z, Zang K, Feng J, Zhao Y, Yang X, Xie Z, Wang PL, Ver Heul AM, Chen L, Samineni VK, Wang YQ, Lavine KJ, Gereau RW 4th, Wu GF, Hu H. A TRPV4-dependent neuroimmune axis in the spinal cord promotes neuropathic pain. J Clin Invest. 2023 Mar 1;133(5):e161507. doi: 10.1172/JCI161507. PMID: 36701202.
Mastrobattista E, Lenze EJ, Reynolds CF, Mulsant BH, Wetherell J, Wu GF, Blumberger DM, Karp JF, Butters MA, Mendes-Silva AP, Vieira EL, Tseng G, Diniz BS. Late-Life Depression is Associated With Increased Levels of GDF-15, a Pro-Aging Mitokine. Am J Geriatr Psychiatry. 2023 Jan;31(1):1-9. doi: 10.1016/j.jagp.2022.08.003. Epub 2022 Aug 26. PMID: 36153290.
Gupta S, Simic M, Sagan SA, Shepherd C, Duecker J, Sobel RA, Dandekar R, Wu GF, Wu W, Pak JE, Hauser SL, Lim W, Wilson MR, Zamvil SS. CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity. Neurol Neuroimmunol Neuroinflamm. 2023 Jan 19;10(2):e200080. doi: 10.1212/NXI.0000000000200080. PMID: 36657993.
2022
Lenze EJ, Voegtle M, Miller JP, Ances BM, Balota DA, Barch D, Depp CA, Diniz BS, Eyler LT, Foster ER, Gettinger TR, Head D, Hershey T, Klein S, Nichols JF, Nicol GE, Nishino T, Patterson BW, Rodebaugh TL, Schweiger J, Shimony JS, Sinacore DR, Snyder AZ, Tate S, Twamley EW, Wing D, Wu GF, Yang L, Yingling MD, Wetherell JL. Effects of Mindfulness Training and Exercise on Cognitive Function in Older Adults: A Randomized Clinical Trial. JAMA. 2022 Dec 13;328(22):2218-2229. doi: 10.1001/jama.2022.21680. PMID: 36511926.
Ostkamp P, Deffner M, Schulte-Mecklenbeck A, Wünsch C, Lu IN, Wu GF, Goelz S, De Jager PL, Kuhlmann T, Gross CC, Klotz L, Meyer Zu Hörste G, Wiendl H, Schneider-Hohendorf T, Schwab N. A single-cell analysis framework allows for characterization of CSF leukocytes and their tissue of origin in multiple sclerosis. Sci Transl Med. 2022 Nov 30;14(673):eadc9778. doi: 10.1126/scitranslmed.adc9778. Epub 2022 Nov 30. PMID: 36449599.
Butt OH, Zhou AY, Caimi PF, Luckett PH, Wisch JK, Derenoncourt PR, Lee K, Wu GF, de Lima MJG, Campian JL, Frank MJ, DiPersio JF, Ghobadi A, Ances BM. Assessment of Pretreatment and Posttreatment Evolution of Neurofilament Light Chain Levels in Patients Who Develop Immune Effector Cell-Associated Neurotoxicity Syndrome. JAMA Oncol. 2022 Nov 1;8(11):1652-1657. doi: 10.1001/jamaoncol.2022.3738. PMID: 36048456.
Yi J, Miller AT, Archambault AS, Jones AJ, Bradstreet TR, Bandla S, Hsu YS, Edelson BT, Zhou YW, Fremont DH, Egawa T, Singh N, Wu GF, Hsieh CS. Antigen-specific depletion of CD4+ T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity. Sci Immunol. 2022 Oct 14;7(76):eabo0777. doi: 10.1126/sciimmunol.abo0777. Epub 2022 Oct 7. PMID: 36206355.
Feng J, Zhao Y, Xie Z, Zang K, Sviben S, Hu X, Fitzpatrick JAJ, Wen L, Liu Y, Wang T, Lawson K, Liu Q, Yan Y, Dong X, Han L, Wu GF, Kim BS, Hu H. Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle. Sci Transl Med. 2022 Jul 13;14(653):eabn4819. doi: 10.1126/scitranslmed.abn4819. Epub 2022 Jul 13. PMID: 35857641.
Manivasagam S, Williams JL, Vollmer LL, Bollman B, Bartleson JM, Ai S, Wu GF, Klein RS. Targeting IFN-λ Signaling Promotes Recovery from Central Nervous System Autoimmunity. J Immunol. 2022 Mar 15;208(6):1341-1351. doi: 10.4049/jimmunol.2101041. Epub 2022 Feb 18. PMID: 35181638.
Ciotti JR, Eby NS, Brier MR, Wu GF, Chahin S, Cross AH, Naismith RT. Central vein sign and other radiographic features distinguishing myelin oligodendrocyte glycoprotein antibody disease from multiple sclerosis and aquaporin-4 antibody-positive neuromyelitis optica. Mult Scler. 2022 Jan;28(1):49-60. doi: 10.1177/13524585211007086. Epub 2021 Apr 19. PMID: 33870786.
2021
Deepak P, Kim W, Paley MA, Yang M, Carvidi AB, Demissie EG, El-Qunni AA, Haile A, Huang K, Kinnett B, Liebeskind MJ, Liu Z, McMorrow LE, Paez D, Pawar N, Perantie DC, Schriefer RE, Sides SE, Thapa M, Gergely M, Abushamma S, Akuse S, Klebert M, Mitchell L, Nix D, Graf J, Taylor KE, Chahin S, Ciorba MA, Katz P, Matloubian M, O'Halloran JA, Presti RM, Wu GF, Whelan SPJ, Buchser WJ, Gensler LS, Nakamura MC, Ellebedy AH, Kim AHJ. Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2 : A Prospective Cohort Study. Ann Intern Med. 2021 Nov;174(11):1572-1585. doi: 10.7326/M21-1757. Epub 2021 Aug 31. PMID: 34461029.
Jiang H, Joshi S, Liu H, Mansor S, Qiu L, Zhao H, Whitehead T, Gropler RJ, Wu GF, Cross AH, Benzinger TLS, Shoghi KI, Perlmutter JS, Tu Z. InVitro and In Vivo Investigation of S1PR1 Expression in the Central Nervous System Using [3H]CS1P1 and [11C]CS1P1. ACS Chem Neurosci. 2021 Oct 6;12(19):3733-3744. doi: 10.1021/acschemneuro.1c00492. Epub 2021 Sep 13. PMID: 34516079.
Hartlehnert M, Börsch AL, Li X, Burmeister M, Gerwien H, Schafflick D, Heming M, Lu IN, Narayanan V, Strecker JK, Kolz A, Peters A, Wu GF, Wiendl H, Sorokin L, Meyer Zu Horste G. Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2023174118. doi: 10.1073/pnas.2023174118. PMID: 34479995.
Brioschi S, Wang WL, Peng V, Wang M, Shchukina I, Greenberg ZJ, Bando JK, Jaeger N, Czepielewski RS, Swain A, Mogilenko DA, Beatty WL, Bayguinov P, Fitzpatrick JAJ, Schuettpelz LG, Fronick CC, Smirnov I, Kipnis J, Shapiro VS, Wu GF, Gilfillan S, Cella M, Artyomov MN, Kleinstein SH, Colonna M. Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. Science. 2021 Jul 23;373(6553):eabf9277. doi: 10.1126/science.abf9277. Epub 2021 Jun 3. PMID: 34083450.
Holloman JP, Axtell RC, Monson NL, Wu GF. The Role of B Cells in Primary Progressive Multiple Sclerosis. Front Neurol. 2021 Jun 7;12:680581. doi: 10.3389/fneur.2021.680581. PMID: 34163430.
Manouchehri N, Hussain RZ, Cravens PD, Esaulova E, Artyomov MN, Edelson BT, Wu GF, Cross AH, Doelger R, Loof N, Eagar TN, Forsthuber TG, Calvier L, Herz J, Stüve O. CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2014492118. doi: 10.1073/pnas.2014492118. PMID: 33785592.
2020
Ciotti JR, Eby NS, Wu GF, Naismith RT, Chahin S, Cross AH. Clinical and laboratory features distinguishing MOG antibody disease from multiple sclerosis and AQP4 antibody-positive neuromyelitis optica. Mult Scler Relat Disord. 2020 Oct; 45:102399.
Ferris ST, Durai V, Wu R, Theisen DJ, Ward JP, Bern MD, Davidson JT 4th, Bagadia P, Liu T, Briseño CG, Li L, Gillanders WE, Wu GF, Yokoyama WM, Murphy TL, Schreiber RD, Murphy KM. cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity. Nature. 2020 Aug 12; 584(7822):624-629.
Esaulova E, Cantoni E, Shchukina I, Zaitsev K, Bucelli RC, Wu GF, Artyomov MN, Cross AH, Edelson BT. Single-cell RNA-seq analysis of human CSF microglia and myeloid cells in neuroinflammation. Neurol Neuroimmunol Neuroinflamm. 2020 May 5; 7(4):e732.
2019
Parker Harp CR, Archambault AS, Cheung M, Williams JW, Czepielewski RS, Duncker PC, Kilgore AJ, Miller AT, Segal BM, Kim AHJ, Randolph GJ, Wu GF. Neutrophils promote VLA-4-dependent B cell antigen presentation and accumulation within the meninges during neuroinflammation. Proc Natl Acad Sci U S A. 2019 Nov 26; 116(48):24221-24230.
Wu GF. X-tra X: An escape to autoimmunity. J Clin Invest. 2019 Aug 12; 130:3536-3538.
Williams JW, Elvington A, Kessler S, Wohltmann M, Wu GF, Randolph GJ. B Cell-Mediated Antigen Presentation through MHC Class II Is Dispensable for Atherosclerosis Progression. Immunohorizons. 2019 Jan 21; 3(1):37-44.
2018
Parker Harp CR, Archambault AS, Sim J, Shlomchik MJ, Russell JH, Wu GF. B cells are capable of independently eliciting rapid reactivation of encephalitogenic CD4 T cells in a murine model of multiple sclerosis. PLoS One. 2018 Jun 26; 13(6):e0199694.
Hoye ML, Archambault AS, Gordon TM, Oetjen LK, Cain MD, Klein RS, Crosby SD, Kim BS, Miller TM, Wu GF. MicroRNA signature of central nervous system-infiltrating dendritic cells in an animal model of multiple sclerosis. Immunology. 2018 Sep; 155(1):112-122.
Wypych TP, Marzi R, Wu GF, Lanzavecchia A, Sallusto F. Role of B cells in TH cell responses in a mouse model of asthma. J Allergy Clin Immunol. 2018 Apr; 141(4):1395-1410.
2017
Wright PW, Archambault AS, Peek S, Bauer AQ, Culican SM, Ances BM, Culver JP, Wu GF. Functional connectivity alterations in a murine model of optic neuritis. Exp Neurol. 2017 May 11.pii: S0014-4886(17)30121-8.
2016
Cantoni C, Cignarella F, Ghezzi L, Mikesell B, Bollman B, Berrien-Elliott MM, Ireland AR, Fehniger TA, Wu GF, Piccio L. Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Acta Neuropathol. 2016 Oct 4.
Lin CC, Bradstreet TR, Schwarzkopf EA, Jarjour NN, Chou C, Archambault AS, Sim J, Zinselmeyer BH, Carrero JA, Wu GF, Taneja R, Artyomov MN, Russell JH, Edelson BT. IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation. J Exp Med. 2016 Feb 8; 213(2):251-71.
2015
Parker Harp CR, Archambault AS, Sim J, Ferris ST, Mikesell RJ, Koni PA, Shimoda M, Linington C, Russell JH, Wu GF. B cell antigen presentation is sufficient to drive neuroinflammation in an animal model of multiple sclerosis. J Immunol. 2015 Jun 1; 194(11):5077-84.
Wu GF, Brier MR, Parks CA, Ances BM, Van Stavern GP. An Eye on Brain Integrity: Acute Optic Neuritis Affects Resting State Functional Connectivity. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2541-6.
Solga AC, Pong WW, Walker J, Wylie T, Magrini V, Apicelli AJ, Griffith M, Griffith OL, Kohsaka S, Wu GF, Brody DL, Mardis ER, Gutmann DH. RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease. Glia. 2015 Apr; 63(4):531-48.
2014
Shin S, Walz KA, Archambault AS, Sim J, Bollman BP, Koenigsknecht-Talboo J, Cross AH, Holtzman DM, Wu GF. Apolipoprotein E Mediation of Neuro-Inflammation in a Murine model of Multiple Sclerosis. J Neuroimmunol. 2014 Jun; 271(1-2): 8-17.
Barnett LG, Simkins HM, Barnett BE, Korn LL, Johnson AL, Wherry EJ, Wu GF, Laufer TM. B Cell Antigen Presentation in the Initiation of Follicular Helper T Cell and Germinal Center Differentiation. J Immunol. 2014 Apr; 192(8): 3607-17.
2013
Kovel ED, Shaner C, Zhang P, du Maine X, Fischer K, Tay J, Chau BN, Wu GF, Miller TM. Method for Widespread MicroRNA-155 Inhibition Prolongs Survival in ALS-Model Mice. Hum Mol Genet. 2013 Oct; 22(20): 4127-35.
Satake A, Schmidt AM, Achambault A, Leichner TM, Wu GF, Kambayashi T. Differential Targeting of IL-2 and T Cell Receptor Signalling Pathways Selectively Expands Regulatory T Cells while Inhibiting Conventional T Cells. J Autoimmun. 2013 Aug; 44: 13-20.
Archambault AS, Carrero JA, Barnett LG, McGee NG, Sim J, Wright JO, Raabe T, Chen P, Ding H, Allenspach EJ, Dragatsis I, Laufer TM, Wu GF. Cutting Edge: Conditional MHC Class II Expression Reveals a Limited Role for B Cell Antigen Presentation in Primary and Secondary CD4 T Cell Responses. J Immunol. 2013 Jul; 191(12): 545-50